This new ultra-sensitive method has the lowest margin of error due to its extremely high sensitivity, providing higher accuracy than is generally available.
The 3rd Generation PSA test performed by American Metabolic Laboratories, due to its high sensitivity, can detect levels of PSA in post radical prostatectomy patients. However, non-prostatic PSA can be found in female sera as well that may be of great importance in breast, ovarian, and other tumors. Unlike for men, the higher the 3rd Generation PSA is in breast cancer patients, the better is the prognosis. PSA-positive tumors showed improved disease-free and overall survival over women with PSA-negative tumors.
Immunofluorometric studies were conducted to analyze serum samples from post radical prostatectomy patients. As a result, very low PSA levels were found by the utilization of the 3rd Generation PSA test.
The exceptionally high sensitivity of the test used by American Metabolic Laboratories, 0.003 ng/mL, allows earlier detection of disease reoccurrence. The traditional cutoff value of 4.0, deemed normal, regrettably will often miss prostate cancer.
Traditional PSA Normal Values are: 0.0 - 4.0
Normal range of 3rd generation PSA for men is 0.00 - 2.80 ng/mL.
Please note the possible significance of the Free-PSA test performed parallel with the Total PSA.
Values obtained with different assay methods should not be used interchangeably.